Monday, July 19, 2010

Modes of Inheritance

There are various modes of inheritance for different mutations/diseases including:
•Autosomal Dominant-females and males are equally likely to have a trait. The trait does not skip generations. Affected children have one affected parent. There is a male to male transmission (meaning that if a dad has it, it is automatically passed on to the suns)
•Autosomal Recessive- males and females are equally likely to inherit the trait. It is known to skip generations. Children can be born to unaffected parents (who are carriers)
•X-linked Recessive-more often occurs in males than females. Generally known to skip one or more generations. Affected males are usually born to unaffected females (carriers)
Females who are affected must have a father that is affected or it has to be autosomal
There is no male-to-male transmission
•X-linked Dominant-twice as many females as males are affected. The mutation doesn’t skip generations. Generally females will pass the trait to half of their children. Sons and daughters are equally affected. All daughters of affected males are affected. There is no male-to-male transmission. Dad gives to 100% female and 0% to males.
•Y-linked-Only males are affected. All sons of affected males will be affected as well. The trait doesn’t skip generations.

What is this inheritance?


Autosomal Dominant!
It does not skip generations. Females and males are equally likely to have the trait. Affected children have one affected parent.

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